Clinical Movement Control and real-life Behavior Analysis for Assistive Systems

Description

This research area addresses the theoretical and experimental understanding of motor and balance dysfunction and the effect of disorders on patients in their daily activities. We develop a wide range of multi-modal assistive tools to support people with neurological movement disorders and psychological disorders. We address the preclinical and clinical phases of various neurological disorders, including Cerebellar Ataxia, Hereditary Spastic Paraplegia, Parkinson’s disease, and Apraxia. Furthermore, multi-modal systems are used to improve therapeutic interventions for mentally ill subjects, e.g., obsessive-compulsive disorders.

  

Current Projects

SSTeP KiZ: smart sensor technology in tele-psychotherapy for children and adolescents with obsessive-compulsive disorder

SSTeP KiZ: smart sensor technology in tele-psychotherapy for children and adolescents with obsessive-compulsive disorder

With sensors that can be worn in everyday life and an intelligent analysis of multi-modal sensor data, SSTeP KiZ aims to significantly improve the treatment options for patients with obsessive-compulsive disorder. We support telemedical treatment of affected children and adolescents in their home environment by integrating data collected with wearables.
Detecting and Quantifying Ataxia-Related Motor Impairments in Rodents Using Markerless Motion Tracking With Deep Neural Networks

Detecting and Quantifying Ataxia-Related Motor Impairments in Rodents Using Markerless Motion Tracking With Deep Neural Networks

Animal models of adult-onset neurodegenerative diseases have significantly enhanced the understanding of the molecular (patho-)mechanisms and have offered enormous potential for therapeutic target evaluation in many neurodegenerative diseases.
Gait in hereditary spastic paraplegia – from axonal degeneration to movement disorder

Gait in hereditary spastic paraplegia – from axonal degeneration to movement disorder

In Hereditary Spastic Paraplegia (HSP) type 4 (SPG4 / SPAST) a length-dependent axonal degeneration in the cortico-spinal tract leads to progressing symptoms of hyperreflexia, muscle weakness, and spasticity of lower extremities. The therapeutical potential for future intervention is likely most promising in the early stages of HSP. Therefore, it is crucial to identify and quantify first changes already in the prodromal phase of HSP patients.
Real-life gait assessment in degenerative cerebellar ataxia: Towards ecologically valid biomarkers

Real-life gait assessment in degenerative cerebellar ataxia: Towards ecologically valid biomarkers

In order to establish ecologically valid biomarkers evaluating treatment-responses really in the patients’ everyday life, we develop multi-variate measures of ataxic gait using wearable sensors, which demonstrate high sensitivity to small differences in disease severity in real-life walking.
  

Finished Projects

The influence of focal cerebellar lesions on the coordination in walking

The influence of focal cerebellar lesions on the coordination in walking

In this study we examined patients with focal cerebellar lesions in order to investigate the influence of different regions of the cerebellum on the performance in a working memory task (n-back task), as well as on gait variability and gait stability during dual task walking.
Smart sensor technology in telepsychotherapy for children and adolescents  SStep-KiZ

Smart sensor technology in telepsychotherapy for children and adolescents SStep-KiZ

Through the use of sensors that can be worn in everyday life and an intelligent analysis of multi-modal sensor data, SSTeP-KiZ aims to significantly improve the treatment options for mentally ill children and adolescents with obsessive-compulsive disorders.
Rehabilitation training exploiting physiotherapy, computer games and biofeedback

Rehabilitation training exploiting physiotherapy, computer games and biofeedback

The symptoms o movement disorders, such as cerebellar ataxia or Parkinon’s disease, can be partially improved y motor training. We have shown that (opposed to the classical view) physiotherapy results in substantial and enduring benefits for patients with cerebellar ataxia, if such training is continuously administered. We exploit biofeedback and computer games to improve such training.
Quantification of subtle motor changes in preclinical stages of neurodegenerative diseases

Quantification of subtle motor changes in preclinical stages of neurodegenerative diseases

Movement disorders such as cerebellar ataxia or Parkinon’s disease result in subtle degradations of motor behavior already long time before the become clinically manifest. Using motion capture technology and machine learning, we try to identify such subtle preclinical motor symptoms.
Motor learning and the functional role of the cerebellum

Motor learning and the functional role of the cerebellum

The cerebellum plays an essential role in motor learning. Combining psychophysics and neuropsychological studies in patients we investigate different types of motor learning mechanisms and the role of the cerebellum.
Influence of action execution on biological motion perception

Influence of action execution on biological motion perception

The perception and execution of motor actions are tightly interlinked, and numerous experiments suggest the existence of common sensory-motor representations.Using a virtual-reality setup we aim to investigate the influence of self-generated body motion on the perception of online generated biological motion in combined motor behaviour and psychophysical studies.
Development of exergames for the motor training in cerebellar ataxia

Development of exergames for the motor training in cerebellar ataxia

Computer games provide a possibility to enhance physiotherapeutic training and to increase the motivation of patients in such training. We develop own games that are optimally adapted to the needs of different patient groups, and specifically cerebellar ataxia patients.
Design and development of a mobile robot supporting the rehabilitation of free walking

Design and development of a mobile robot supporting the rehabilitation of free walking

Current walking rehabilitation is mainly restricted to treadmill walking in order to train basic rhythmic walking patterns. Together with the Fraunhofer IPA (Stuttgart) we designed a new robot platform to train walking in complex situations (turning, standing up, etc.).
Cost-efficient system for movement quantification in neurology

Cost-efficient system for movement quantification in neurology

The Microsoft Kinect sensor for computer games allows robust body motion tracking for relatively low cost. We use this technology for the analysis of patient movements and develop cheap systems for the quantification of movement deficits that can be deployed at home or simultaneously at multiple places for multi-center studies.
Cerebellar involvement in the facilitation of action perception by concurrent motor activity

Cerebellar involvement in the facilitation of action perception by concurrent motor activity

The execution of motor behavior influences concurrent visual action observation, and especially the perception of biological motion. Exploiting Virtual Reality technology, we have studied how the cerebellum contributes to action-perception coupling, comparing cerebellar patients with controls.
  

Publications

Christensen, A., Taubert, N., in ’t Veld, E. M., de Gelder, B. & Giese, M. A. (2024). Perceptual encoding of emotions in interactive bodily expressions. iScience. VOLUME 27, ISSUE 1, 108548, JANUARY 19, 2024. [More] 
Nemeth, A., Antoniades, C., Dukart, J., Minnerop, M., Rentz, C., Schuman, B.-J. et al. (2023). Using Smartphone Sensors for Ataxia Trials: Consensus Guidance by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers. The Cerebellum, 1-12. [More] 
Ilg, W., Milne, S., Schmitz‑Hübsch, T., Alcock, L., Beichert, L., Bertini, E. et al. (2023). Quantitative Gait and Balance Outcomes for Ataxia Trials: Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers. The Cerebellum. [More] 
Thierfelder, A., Severitt, B., Klein, C. S., Alt, A. K., Hollmann, K., Bulling, A. et al. (2023). Gaze behaviour in adolescents with obsessive-compulsive disorder during exposure within cognitive-behavioural therapy. . [More] 
Seemann, J., Traschütz, A., Ilg, W. & Ilg, W. (2023). 4‐Aminopyridine improves real‐life gait performance in SCA27B on a single‐subject level: a prospective n‐of‐1 treatment experience. Journal of Neurology (published online 13 July 2023). [More] 
Seemann, J., Loris, T., Weber, L., Synofzik, M., Giese, M. A. & Ilg, W. (2023). One Hip Wonder: 1D-CNNs Reduce Sensor Requirements for Everyday Gait Analysis. ICANN 2023. [More] 
Lang, J., Giese, M. A., Ilg, W. & Otte, S. (2023). Generating Sparse Counterfactual Explanations For Multivariate Time Series. ICANN 2023. [More] 
Laßmann, C., Ilg, W., Rattay, T. W., Schöls, L., Giese, M. A. & Haeufle, D. F. (2023). Dysfunctional neuro-muscular mechanisms explain gradual gait changes in prodromal spastic paraplegia. Journal of NeuroEngineering and Rehabilitation. Jul 15;20(1):90. [More] 
Timmann, D., Ernst, T., Ilg, W. & Donchin, O (2023). Lesion-Symptom Mapping, chapter Essentials, pages 479–483. Springer, Cham. [More] 
Ilg, W. & Timmann, D (2023). Motor Rehabilitation of Cerebellar Disorders, chapter Essentials, pages 709–714. Springer, Cham. [More] 
Timmann, D. & Ilg, W (2023). Drugs in Selected Ataxias, chapter Essentials, pages 699–703. Springer, Cham. [More] 
Primbs, J., Ilg, W., Thierfelder, A., Severitt, B., Hohnecker, C. S., Alt, A. K. et al. (2022). The SSTeP-KiZ System—Secure Real-Time Communication Based on Open Web Standards for Multimodal Sensor-Assisted Tele-Psychotherapy. Sensors, 22(24), 9589. [More] 
Ilg, W., Müller, B., Faber, J., van Gaalen, J., Hengel, H., Vogt, I. R. et al (2022). Digital gait biomarkers, but not clinical ataxia scores, allow to capture 1-year longitudinal change in Spinocerebellar ataxia type 3 (SCA3) . MedRxiv Preprint. [More] 
Vogel, A. P., Magee, M., Torres-Vega, R., Medrano-Montero, J., Cyngler, M. P., Kruse, M. et al. (2020). Features of speech and swallowing dysfunction in pre-ataxic spinocerebellar ataxia type 2. Neurology, 95(2):e194-e205. [More] 
Steiner, K. M., Thier, W., Batsikadze, G., Ludolph, N., Ilg, W. & Timmann, D. (2020). Lack of effects of a single session of cerebellar transcranial direct current stimulation (tDCS) in a dynamic balance task. Journal of Neurology, 267, pages1206–1208(2020). [More] 
Salatiello, A. & Giese, M. A (2019). Learning of generative neural network models for EMG data constrained by cortical activation dynamics(B). CNS Conference 2019, 13-17 July, Barcelona, Spain . [More] 
Fleszar, Z., Mellone, S., Giese, M. A., Tacconi, C., Becker, C., Schöls, L. et al. (2019). Real-time use of audio-biofeedback can improve postural sway in patients with degenerative ataxia. Ann Clin Transl Neurol, 6(2), 285-294. [More] 
Ludolph, N., Giese, M. A., Mueller, O. M., Goericke, S. L., Ernst, T., Timmann, D. et al (2016). Cerebellar regions involved in fine motor control and learning to control dynamic objects. NCM 2016, Montego Bay, Jamaica . [More] 
Steiner, K. M., Thier, W., Enders, A., Ludolph, N., Ilg, W. & Timmann, D (2015). Cerebellar tDCS does not improve learning but impedes performance in a complex whole body dynamic balance task . [More] 
Goldberg, H., Christensen, A., Flash, T., Giese, M. A. & Malach, R. (2015). Brain activity correlates with emotional perception induced by dynamic avatars. NeuroImage, 122:306-317. [More] 
Ilg, W., Golla, H. & Giese, M. A. (2006). Velocity-dependent stability of gait for patients with balance impairments can be explained by biomechanical stabilization. XVIIth Conference of the International Society for Postural and Gait Research, 24(2), S113-S114. [More]