@inbook{inbook,
author = "Christian La{\ss}mann and Ludger Sch{\"o}ls and Martin A. Giese and Daniel Haeufle and Winfried Ilg",
abstract = "Hereditary spastic paraplegia is characterized by progressive spasticity and muscle weakness, significantly impairing gait. In neuro-musculoskeletal models, gradually increasing hyperreflexia could simulate severity-related gait patterns. This shows a potential application of neuromusculoskeletal models in predicting outcomes of treatments managing spasticity. As a first step, this case-study investigates the efficacy of Botulinum-Toxin-A in improving gait kinematics in a 54-year-old male with HSP and impaired gait. Instrumented gait analysis was conducted before and after treatment using dynamic time warping to compare the participant’s gait to healthy controls. Post-treatment results showed increased segmental angle range of motions and gait speed. The dynamic time warping analysis revealed a 13% restoration towards a healthy gait, indicating that kinematic analyses effectively quantify BoNT-A treatment effects in HSP patients.",
doi = "10.1007/978-3-031-77584-0_79",
isbn = "978-3-031-77583-3",
month = "12",
pages = "406-410",
title = "{Q}uantifying the {R}estoration of a {N}orm-{L}ike {G}ait {P}attern from {M}id-{F}oot {S}trike by {B}otulinum-{T}oxin-{A} {T}reatment in a {P}atient with {H}ereditary {S}pastic {P}araplegia",
year = "2024",
}