@article{Beichert20242,
author = "Lukas Beichert and Jens Seemann and Christoph Kessler and Andreas Trasch{\"u}tz and Doreen M{\"u}ller and Katrin Dillmann-Jehn and Ivana Ricca and Sara Satolli and Ayşe Nazli Başak and Giulia Coarelli and Dagmar Timmann and Cynthia Gagnon and van de Warrenburg, Bart P. and Winfried Ilg and Matthis Synofzik and Rebecca Sch{\"u}le",
abstract = "Background and Objectives With targeted treatment trials on the horizon, identification of sensitive and valid outcome measures becomes a priority for the >100 spastic ataxias. Digital-motor measures, assessed by wearable sensors, are prime outcome candidates for SPG7 and other spastic ataxias. We here aimed to identify candidate digital-motor outcomes for SPG7 – as one of the most common spastic ataxias – that: (i) reflect patient-relevant health aspects, even in mild, trial-relevant disease stages; (ii) are suitable for a multi-center setting; and (iii) assess mobility also during uninstructed walking simulating real-life.",
doi = " https://doi.org/10.1101/2024.01.09.24301064",
journal = "MedRxiv preprint",
month = "January",
title = "{T}owards patient-relevant, trial-ready digital motor outcomes for {SPG}7: a cross-sectional prospective multi-center study ({PROSPAX})",
url = "https://www.medrxiv.org/content/10.1101/2024.01.09.24301064v1",
year = "2024",
files = "2024.01.09.24301064v1.full.pdf",
}