Turning movements in real life capture subtle longitudinal and preataxic changes in cerebellar ataxia
Year:
2021
Type of Publication:
Article
Authors:
Thierfelder, Annika |
Seemann, Jens |
John, N. |
Giese, Martin A. |
Schöls, L. |
Timman, D. |
Synofzik, M. |
Ilg, Winfried |
Journal:
bioRxiv |
Month:
March
BibTex:
Abstract:
OBJECTIVES Clinical and regulatory acceptance of upcoming molecular treatments in degenerative ataxias might greatly benefit from ecologically valid endpoints which capture change in ataxia severity in patients’ real life. This longitudinal study aimed to unravel quantitative motor biomarkers in degenerative ataxias in real life turning movements which are sensitive for changes both longitudinally and at the preataxic stage. |