In this chapter, methods will be introduced which are currently available to perform lesion-symptom mapping in patients with focal and degenerative cerebellar disease. At the beginning of the chapter, strength and weaknesses inherent in studies on localization of cerebellar function in these different patient populations will be discussed. Next, methods of lesion-symptom mapping in focal cerebellar disease will be explained in more detail including lesion delineation, lesion normalization, and descriptive and inferential statistical analysis. Finally, methods of lesion-symptom mapping in cerebellar degeneration and available atlases of the cerebellum in stereotaxic space will be introduced.